A late Bronze Age Hittite shrine in northern Syria contained a bronze statue of a god holding a serpent in one hand and a staff in the other. In many Meso-American cultures, the serpent was regarded as a portal between two worlds. The snake became immortal, and Gilgamesh was destined to die. This connection depends in part on the experience that venomous snakes often deliver deadly defensive bites without giving prior notice or warning to their unwitting victims. He is sometimes referred to as "Ananta-Shesha," which means "Endless Shesha".
Asclepiusthe son of Apollo and Koronis, learned the secrets of keeping death at bay after observing one serpent bringing another which Asclepius himself had fatally wounded back to life with healing herbs.
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He is often seen as the son of the snake goddess Renenutet. In Dahomey mythology of Benin in West Africa, the serpent that supports everything on its many coils was named Dan. Because of his association with snakes, he is sometimes disguised as Moses, who carried a snake on his staff. The constellation Serpens represents a snake being tamed by Ophiuchus the snake-handler, another constellation. Friedlander, in The Golden Wand of Medicine: Frog Salamander Toad Toadstone.